Monkeypox (mpox) virus: Classification, origin, transmission, genome organization, antiviral drugs, and molecular diagnosisReview Published on 2023-04-012023-06-09 Journal: Journal of infection and public health [Category] Fulltext, 원숭이두창, [키워드] Diagnosis Genome Monkeypox virus mpox susceptibility Transmission. [DOI] 10.1016/j.jiph.2023.02.003 PMC 바로가기 [Article Type] Review
Impact of BSG/CD147 gene expression on diagnostic, prognostic and therapeutic strategies towards malignant cancers and possible susceptibility to SARS-CoV-2Article Published on 2023-03-012023-07-11 Journal: Molecular biology reports [Category] COVID19(2023년), [키워드] 5′-uridylic acid (UMP) Cordycepin (CD) COVID-19 Malignant cancers N6 N6-(2-hydroxyethyl) adenosine (HEA) N6-dimethyladenosine (m6 2a) susceptibility The BSG gene. [DOI] 10.1007/s11033-022-08231-1 PMC 바로가기
Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Impact of COVID-19 pandemic on cancer care: A cross-sectional study of Egyptian patients’ perspectives and concernsResearch article Published on 2022-12-012022-10-05 Journal: Journal of cancer policy [Category] 진단, [키워드] and knowledge beliefs Adjustment Analysis Cancer Cancer care adjustments Care Community Complication conducted COVID-19 COVID-19 and healthcare accessibility COVID-19 infection COVID-19 pandemic cross-sectional Diagnosis Egyptian cancer patients and survivors Follow-up group healthcare healthcare facility Healthcare provision Impact Infection infection control information knowledge less Lower majority media Ministry of Health Modification of cancer treatment occur online survey pandemic Participants Patient Patients’ concerns Patients’ perspectives Perspective Policy probable COVID-19 infection proportion questionnaire reduced remote consultations reported required Resilience Result risk of COVID-19 Safe susceptibility Treatment [DOI] 10.1016/j.jcpo.2022.100359 [Article Type] Research article
Massive macroglossia, a rare side effect of COVID-19: clinical, histologic, and genomic findings in COVID-19-positive versus COVID-19-negative patientsArticle Published on 2022-12-012022-11-16 Journal: Oral and maxillofacial surgery [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] African analysis CD45 COVID-19 Genetic Genetic predisposition Genetic testing genomic histologic histology Histopathology identify IHC immune cells immune response immunohistochemistry include Inconclusive individual infected with SARS-CoV-2 Intubated massive oral oral pathology oral surgery Oral surgery. organ Patient persistence Result retrospective robust Secondary objective Sequencing Side effect susceptibility tissue samples tissues whole-exome sequencing [DOI] 10.1007/s10006-021-01031-0 PMC 바로가기
Association of iron-related biomarkers with severity and mortality in COVID-19 patientsArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] Activation Analysis analyzed association AUC biological processes Biomarker can be used characterized Combination continuous monitoring contribute Control controls Course COVID COVID 19 COVID-19 COVID-19 patient cutoff point Deceased decrease deficiency demonstrated discharged ferritin healthy individual highest IL-6 immune responses immune system immunomodulatory individual infected with COVID-19 Infection Inflammation iron marker material Mild moderate Mortality multiple regression model outcome oxidative stress parameter patients with COVID-19 receiver operating characteristic recruited regulate required ROC ROC Curve SARS-CoV-2 patients sensitivity serum severe disease severity shown significant difference significantly significantly increased specificity stepwise AIC selection survival susceptibility the cytokine storm the median trace Trace element Trace metals Transferrin Transferrin. variable variety viral infections [DOI] 10.1016/j.jtemb.2022.127075 PMC 바로가기
Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics InitiativeArticle Published on 2022-11-032022-11-15 Journal: PLoS Genetics [Category] SARS, 변종, 진단, [키워드] Analysis analysis association chromosome Cohort controls country COVID-19 Deleterious disease expected Genetic genetics Genome-wide association study identify increase in initiative loci outcome outcomes Pathogenesis performed rare variant Result severe disease Support susceptibility the SARS-CoV-2 TLR7 Toll-like receptor variant whole-genome sequencing with COVID-19 [DOI] 10.1371/journal.pgen.1010367 PMC 바로가기
Humoral and Cellular Immune Response to Covid-19 Vaccination in Patients with Chronic Graft-versus-Host Disease on ImmunosuppressionArticle Published on 2022-11-012022-11-15 Journal: Transplantation and cellular therapy [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome amplified anti-spike antibody antibody association cellular Characteristics chronic coronavirus COVID-19 COVID-19 vaccination demonstrated detect disease dose Efficacy enrolled Escalation evaluated group HCT humoral Humoral response immune immune response Immunosuppression immunosuppressive immunosuppressive therapy Infection initial management mononuclear cell natural infection neutralizing antibody Neutralizing antibody response neutralizing antibody titers Patient patient population patients Peripheral blood positive positive correlation present progression proportion Quantitative receiving Responder responders response Sample size SARS-CoV-2 sequence Significant statistical difference susceptibility T cell T cell receptor T cell response T cell responses the antibody response the patient therapy unique vaccination Vaccine vaccine. was measured were measured worsened worsening [DOI] 10.1016/j.jtct.2022.08.026 PMC 바로가기
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expressionArticle Published on 2022-11-012022-11-16 Journal: Life sciences [Category] SARS, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression TMPRSS2. uninfected cell various tissue viral infection Viral load viral replication were assessed western blot [DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기
Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohortArticle Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Biomarker Biomarkers CCL5 Cell cellular response characterized chemokine children Chilean clinical clinical feature Cohort Complication convalescent coronavirus COVID-19 CXCL10 CXCL8 Cytokine storm deep degranulation disease dysregulation elevated enzyme-linked immunosorbent enzyme-linked immunospot flow cytometry gastrointestinal involvement humoral identify IL-10 IL-18 IL-6 immune dysregulation immune response Immunity Inflammation Inflammatory intestinal inflammation laboratory biomarker Latin life-threatening Ligand MIS-C mononuclear cell MOST motif multisystemic multisystemic inflammatory syndrome in children. natural killer neutralizing antibody neutralizing antibody assays NK cell NK cell deficiency occur organ Patient patients predict representing reveal robust severe multisystemic severity Shock significantly stools susceptibility sustained syndrome T-cell activation underlie was increased was performed [DOI] 10.1016/j.jaci.2022.09.006 PMC 바로가기